fig3

Figure 3. Androgen pathway in triple negative breast cancers. Bicalutamide acts as an inhibitor competing with DHT on cytoplasmic AR. Abiraterone acetate inhibits CYP17, thus reducing testosterone synthesis in adrenal tissue. DHT: dihydrotestosterone; AR: androgen receptors; CYP17: cytochrome P450 17 alpha-hydroxylase; ACTH: adrenocorticotropic hormone; DHEA: dehydroepiandrosterone