fig1

Figure 1. Schematic of androgen-driven ERG expression following TMPRSS2:ERG fusion. Fusion of the 5’ regulatory region of the TMPRSS2 gene (21q22.3) - including an upstream androgen response element (ARE) - to the coding region of the ERG oncogene (21q22.2) results in a fusion product in which ERG expression is induced in an androgen-responsive manner. This fusion can be detected using fluorescence in situ hybridization^[28] or indirectly through ERG immunohistochemistry