fig4

Figure 4. UMAP plots of clustering solutions using different methods of normalization. LogNormalize (A, D baseline) was compared to RC (B, E) and CLR (C, F) normalization methods. Colored circles are manually placed around clusters that were annotated similarly. BCL_bc: B cells; END_en: endothelial cells; EPI_ep: epithelial cancer cells; FIB_fi: fibroblasts; MAC_ma: macrophages. UMAP: uniform manifold approximation and projection