fig2

Figure 2. Main pathways targeted by somatic mutations in SMZL. Recurrently mutated genes in SMZL preferentially target physiologically important pathways, including the Notch pathway, chromatin remodelling, cell cycle control and canonical and non-canonical NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation. NF-κB can be activated through BCR, TLR and BAFF-R signalling. Genes encoding proteins in grey have a mutational frequency greater than 10% within SMZL cohorts. SMZL: Splenic marginal zone lymphoma; BCR: B-cell receptor; TLR: toll-like receptor; BAFF-R: B-cell activating factor receptor.