fig1

Figure 1. Extended high-risk chronic lymphocytic leukemia (CLL) pedigree from the Utah Population Database. (A) Full extent of CLL cases captured from the common ancestor, with four wives. (B) Reduced pedigree, terminating at each sampled CLL case and only containing the intermediate connecting relatives. “+” indicates sharing of the significant shared 2q22.1 region; “(+)” indicates obligate sharing with a heme malignancy or solid cancer; and “-” indicates non-sharing.