fig1

Figure 1. Omics strategies to uncover the mechanisms of resistance in CART cell therapy. Strategies involve studying (A) the tumor itself, (B) the TME, or (C) the T cells themselves. These studies are performed before and/or after infusion of CART cells. Studies specific to T cells include TCRB sequencing, lentiviral integration sites, and phenotype. DNA and RNA sequencing as well as gene regulation are studied. Classification models can also be created or used. Created with BioRender.com. CART: chimeric antigen receptor T cell; TME: tumor microenvironment; TCRB: T cell receptor beta; DNA: deoxyribonucleic acid; RNA: ribonucleic acid.