fig1

Figure 1. Genetic support for dysregulated NR-mediated signaling in mental illness. Consistently, ~15% of risk loci in PDs harbor NTC-encoding genes. Manhattan plots show the SNP-based association landscape for each of the five psychiatric disorders [attention deficit hyperactivity disorder (ADHD)^[11], schizophrenia (SZ)^[7] (for presented analyses, data from a newer, larger GWAS^[70] were used), bipolar disorder (BPD), autism spectrum disorder (ASD), and major depressive disorder (MDD)] with the red dotted line marking the significance cut-off for genome-wide significantly associated signals. Brain-expressed protein-coding genes within each locus are shown as columns of tiles, where NTC encoding genes are highlighted in red. GWS: Genome-wide significant; NTC: NR transcriptomic complex; HRE: hormone response element; NR: nuclear receptor.