fig3

Large-scale genomic data-mining implicates dysregulated nuclear receptor-mediated signaling in mental illness

Figure 3. MAGMA analyses of HRE gene set association using summary statistics from ADHD, ASD, MDD, BPD, SZ, and cross disorder (CDG2) GWAS as well as from a range of non-psychiatric GWASs [Alzheimer’s disease (AD), type 2 diabetes (T2D), body mass index (BMI), heart failure (HF), height, and COVID-19]. The red dotted line marks Bonferroni-adjusted significance cut-off. ADHD: Attention deficit/hyperactivity disorder; ASD: autism spectrum disorder; HRE: hormone response element; MDD: major depressive disorder; BPD: bipolar disorder; SZ: schizophrenia.

Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
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