fig6

Figure 6. NR-signaling pathways with high genetic risk burden. Illustrated are individual NRs and their experimentally validated associated NTC, their HRE target genes, resulting transcripts, selected ligands, and linked epidemiological risks, as well as selected psychiatry-relevant drugs. The illustration is divided into experimental levels (epidemiological, molecular, genetic, and pharmacological) as well as the developmental stage/brain structure in which the individual NR-encoding genes peak in expression. Entities associated with SZ are highlighted in blue, MDD in green, ASD in grey, CD in orange, and multiple PDs in black. NTC: NR transcriptomic complex; HRE: hormone response element; NR: nuclear receptor; SZ: schizophrenia; MDD: major depressive disorder; ASD: autism spectrum disorder; CD: cross-disorder; PDs: psychiatric disorders.