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Figure 1. Dietary feeding of the KRE inhibits the occurence of HG-PIN and prostate adenocarcinoma in TRAMP mice. (A) A simple illustration of prevention protocol by the KRE in the TRAMP model. (B) Percentages of HG-PIN or adenocarcinoma lesions in the prostates of 12-week-old, vehicle control vs. 0.3% or 0.6% KRE conatining food administrated to TRAMP mice. The prostates were from 8 mice in each group, and the total number of prostate acinus was counted. Fisher exact test show P < 0.05. (C) Prostates in 12-weeks-old, vehicle control vs. 0.3% or 0.6% KRE containing food fed TRAMP mice were examined by H&E staining and histological evaluation. 200× magnifications of images are shown. KRE: Kava root extract; HG-PIN: high-grade prostatic intraepithelial neoplasia; TRAMP: transgenic adenocarcinoma of the mouse prostate. *P < 0.05 and **P < 0.01, respectively.