fig6

Figure 6. Patient #12 [22.6 (left) and 26.4 years (right)] with severe ABCA4-IRD with macular and peripheral atrophy. (A) FAF: multiple flecks with increased or reduced intensity with peripapillary sparing. (B) NIA: centrally large areas and towards the periphery flecks with reduced intensity, peripapillary sparing. (C) W-OCT: subretinal material (blue arrow) corresponds to areas of reduced FAF (A) and NIA (B) intensity which enlarge during follow-up. The choroidal excavation outside of the macula (green arrows) progressed as well as indicated by the absence of the line of increased reflectance towards the choroid in this and adjacent scans at the follow-up examination.