fig1

Figure 1. The diagrams illustrating properties of composite indices SIPRS constructed for the rs16970024 SNP (on the left) and SIPRS for rs697221 SNP on the right. The vertical axis represents proportions of phenotypic variances (R²) explained by the composite indices. Each pillar characterizes a version of the SIPRS index corresponding to the P-value threshold (shown under the pillar at the horizontal axis). Nine pillars at each diagram correspond to nine SIPRSs indices that summarize associations of different numbers of SNP pairs with survival traits. The numbers on the top of each pillar describe properties of the corresponding index: (1) the first line on the top shows the number of SNP pairs corresponding to the P-value threshold (shown below this pillar at the horizontal axis); (2) the second line from the top shows the value of R²; (3) the third line from the top represents the P-value of association of this SIPRS index with survival trait.