fig1

Figure 1. A diagram to illustrate the role of oncolytic virus therapy in stimulating natural killer cells and initiating both an innate and adaptive immune response directed towards tumour cells. Highlighted are approaches under investigation to enhance OV therapeutic efficacy, either by incorporation into the virus or in a combination treatment strategy. Also, highlighted are potential hurdles to OV therapy related to premature viral clearance by NK cells. Illustrations of the OV, tumour cell, NK cell and adaptive immune cells have been used and adapted with permission from Servier Medical ART (https://smart.servier.com/). OV: Oncolytic virus; NK: natural killer.