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From: Alternative isoforms of RNA polymerase III impact the non-coding RNA transcriptome, viability, proliferation and differentiation of prostate cancer cells

Alternative isoforms of RNA polymerase III impact the non-coding RNA transcriptome, viability, proliferation and differentiation of prostate cancer cells

Figure 2. MAF1 regulation of pol III may depend on subunit composition. POLR3GL (orange) is the ancestral paralogue and is expressed ubiquitously; it allows repression of pol III by MAF1. POLR3G (purple) is enriched in stem and cancer cells; its incorporation may make pol III more resistant to MAF1 and thereby contribute to unregulated transcription and selective induction of ncRNAs such as BC200 and snaR. ncRNAs: Noncoding RNAs.

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