fig2

Figure 2. Total cholesterol and methylsterol/total sterol ratio through proband’s life. (A) Simvastatin and CoQ10 were initiated at time of diagnosis. (B) Pravastatin added at 6.4 years of age, after an increase in methylsterol levels. Purple line: methylsterol/total sterol ratios. Blue line:total cholesterol levels. Red dotted line：normal methylsterol/total sterol ratio (< 0.1%). Green dotted line: lower normal limit of total cholesterol (< 140 mg/dL).