fig3

Figure 3. Binned Polygenic Risk Scores are shown on the x-axis and the frequency of occurrence in the population is shown on the y-axis. This was determined by summing the product of the number of copies of each genetic risk variant with the hazard risk ratio for CAD. Shown in blue is the distribution of the Genetic Risk Score for CAD as determined from a reference population using the same genotyping array technology and bioinformatics pipeline. Shown in orange is the distribution of the PRS scores in 205 patients genotyped as part of the ongoing clinical study, Genetic Risk Score for CAD. The risk cutoff of 18.15 was determined using the reference population and setting a threshold at the top 20%. Given the observation that these risk variants frequently occur throughout the population, it is not surprising that most of the population has many of these risk variants.