fig1

Figure 1. A quantitative analysis of 100 pancreases obtained from individuals in the United Kingdom in the mid-1930, including newly-born infants and adults up to the age of 64 years, all of whom apparently had normal nutrition and died from different causes including pneumonia, cerebral hemorrhage, perforated gastric ulcer burns, showing the proportional weight of islets and their increase in size over time, reaching a plateau in early adulthood. The small islet mass and its plateau in early adulthood might contribute to the marked increase in diabetes prevalence given the average adult body weight of 60-70 kg today compared to 50 kg nearly 100 years ago (reproduced with permission)^[26].