- Dr. Stacey J. Winham
- Quantitative Health Sciences, Mayo Clinic, Jacksonville, FL, USA.
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Special Issue Introduction
Although not translated to protein, long non-coding RNA (lncRNA) are widely expressed and play an essential role in gene regulation in ways similar to and distinct from the messenger (mRNA). Through gene regulation, lncRNA is vital in various biological processes, and could be critical to biological mechanisms of both development and disease. The expression of one particular lncRNA, Xist (X inactive specific transcript), is responsible for triggering the process of X chromosome inactivation early in development, which silences one of the two copies of the X chromosome in females. This issue will focus on the role of X chromosome inactivation and other long non-coding RNAs in biological processes and gene regulation, as well as their relevance to disease development, progression, and novel therapeutics.
Submission Deadline31 Aug 2022