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Type: Case Report
Title: liquid biopsy and Müllerian uterine sarcoma: a new tool for cancer detection? A case report
Authors: Francesca Malentacchi1, Ivo Noci1, Giulia Fantappiè1, Dora Pavone1, Irene Turrini1, Serena Pillozzi2
Affiliations: 1Department of Clinical, Experimental and Biomedical Sciences, University of Florence, Italy
2Medical Oncology Unit, AOU Careggi, Firenze, Italy
Abstract: Liquid biopsy is an emerging tool for the screening, diagnosis and monitoring treatment of cancer.
Uterine sarcomas comprise a small percentage of uterine malignancies (less than 10%) that have a higher incidence rate in women aged >50. Müllerian adenosarcoma is a subtype of uterine sarcoma a mesenchymal subtype, is a biphasic tumor composed of both sarcomatous stroma and benign epithelium. Hysterectomy and bilateral sapingo-oopherectomy, avoiding morcellation, are the standards of care.
Up to now no molecular target exists for treatment and for detection or monitoring. This case report evidences that liquid biopsy and circulating tumor DNA analysis may represent a new tool for characterization of Müllerian sarcoma and may open new prospective for management of patients affected by this cancer type.