Guest Editor(s)
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- Dr. Rebecca Sims
- Division of Psychological Medicine and Clinial Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.
Website | E-mail
Special Issue Introduction
Neurodegenerative diseases are a collection of devastating conditions afflicting a growing proportion of the world’s population. Despite the identification of both disease-causing genes and genes that influence disease risk, effective treatment solutions remain elusive. The complexity of the common neurodegenerative disease is now evident given the role of environmental cues, the polygenic nature of the disease, and the multi-functional pathways implicated temporally in etiology and progression. Extensive research into the use of genetics and biomarkers for accurate diagnosis, iPSC replacement therapy for Mendelian disease, and the development of disease-relevant cellular and animal models for therapeutic screening gives great hope for timely clinical impact. This special issue on “Neurodegenerative Disease: from genetics to treatment” aims to provide the reader a broad overview of the ongoing and prospective research across:
1. Genetic discovery and risk profiling
2. Utility and integration of ‘omics’ data
3. Development of model systems
4. Current therapeutic concepts
Keywords
Neurodegenerative disease, genetics, treatment
Submission Deadline
31 Jan 2022
Journal of Translational Genetics and Genomics
