- Dr. Miroslav Blumenberg
- Department of Dermatology, NYU School of Medicine, New York, NY, USA.
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Special Issue Introduction
Skin, for its easy accessibility, has been among the first organs targeted by many innovative medical technologies. Indeed, genomics, the study of all genes in an organism (genome), and transcriptomics, analysis of the expression of RNA and protein-coding genes, have greatly contributed to our understanding of skin function and its perturbations caused by diseases. Many inherited skin disorders, genodermatoses, have been precisely mapped and their molecular effects elucidated. A tour-de-force genome-wide association study, GWAS, of psoriasis, a disease with a substantial genetic component, identified numerous loci associated with this disorder. Genomics identified specific genetic changes causing skin cancers, melanomas, squamous, and basal cell carcinomas, leading to breakthroughs in their treatments. Major technical advance, single-cell transcriptomics, has been used to identify the T cells in immune and inflammatory diseases, including diseases with autoimmune blistering and the changes associated with skin aging. Genomics and transcriptomics have been applied to studies of diversity of skin pigmentation and studies of skin appendages: hair, nails, and glands. The exciting new field, cutaneous microbiome research, mapped the microbial landscape of human skin and identified some of the mechanisms that determine the differences between commensal skin bacteria and pathogens. These advances in genetics and transcriptomics of skin diseases will lead toward personalized medicine in dermatology.
1.Methodological advances in genetics and transcriptomics of skin diseases.
2.Inflammatory and immunological diseases of skin.
4.Aging, skin pigmentation, and appendages.
KeywordsGenetics, transcriptomics, skin diseases
Submission Deadline28 Feb 2022