fig2

Figure 2. Strategies used to search for new X chromosome inactivation (XCI) factors (XCIFs) in all 10 screens performed. Seven genetic screens^{[32-34,40-43]} and three proteomics screens^[47-49] identified more than 500 XCIFs. So far, 87 of them have been validated using candidate approaches. Screens highlight in yellow were performed in embryonic cells and focus on establishment of XCI, screens highlight in blue were performed in differentiating cells and focus on maintenance of XCI and possibility of X chromosome reactivation (XCR)