fig1

Figure 1. Pedigree of the family, with proband indicated with arrow. Black symbols represent individuals who are clinically affected with cardiomyopathy. Open shading indicates individuals who do not have features of cardiomyopathy. Subject numbers in italics (lower left) indicate the two individuals who are heterozygous for the ADD3 variant c.169C>T R57X (all other family members have wild type genotype, CC). The FLNC genotype at c.4636G>A G1546S is shown for each family member in blue; the A allele segregates with the clinical condition