fig2

Figure 2. Gene expression regulation by a genetic variant. (A) cis-eQTL affects the expression of transcripts from nearby genes [generally within ± 1 MB of transcription start site (TSS)]. (B) trans-eQTL affects the expression of the distant gene ( > 1 MB) either on the same chromosome or elsewhere in the genome. eQTL: Expression quantitative trait loci.