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  • Topic: MicroRNAs in Allergic Diseases|Open Access

    MicroRNAs in atopic dermatitis: a review

    Neeti Bhardwaj
    Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease, generally the first clinical manifestation of atopy and the start of atopic march. Effective treatment of AD could potentially interrupt the progression of atopic march. MicroRNAs (miRNAs), a recently described class of gene expression regulators in inflammatory conditions, affect expression of numerous proteins. The role of miRNAs has been investigated in several atopic conditions, including asthma, eosinophilic esophagitis, allergic rhinitis as well as atopic dermatitis. They have been shown to be involved in the... Read more
    J Transl Genet Genom 2017;1:15-22
    Published on: 17 Nov 2017  | Viewed:218  | Downloaded:13
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  • Topic: Reversing X Chromosome Inactivation as a New Therapeutic Treatment for X-linked Diseases|Open Access

    Reversal of X chromosome inactivation: lessons from pluripotent reprogramming of mouse and human somatic cells

    Irene Cantone
    X chromosome inactivation (XCI) is a strategy used by mammals to silence genes along one of the two female X chromosomes and equilibrate expression dosage between XY males and XX females. This epigenetically-inherited silencing is established during early embryonic development and maintained thereafter through cell divisions. Seeding of multiple repressive epigenetic marks along the inactive X chromosome (Xi) makes inactivation extremely robust and difficult to reverse upon single genetic perturbations. Reversal of XCI has, however, been observed when somatic cells are reprogrammed towards... Read more
    J Transl Genet Genom 2017;1:1-14
    Published on: 16 Nov 2017  | Viewed:285  | Downloaded:11
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Journal of Translational Genetics and Genomics
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